Midkine as a novel biomarker for contrast-induced acute kidney injury

Contrast-induced acute kidney injury (CI-AKI) is an intrinsic caused by contrast injection in susceptible individuals. Although the pathophysiological mechanisms which agents induce have not been completely explained, direct and indirect effects, as well hemodynamic perturbations, suggested. Renal effects develop immediately after injection, and, theoretically, they could be detected early using a sensitive biomarker. Recently, studies conducted to determine specific biomarkers guide diagnosis of CI-AKI thus improve outcomes these patients. Midkine (MK) heparin-binding growth factor that balances cell growth, survival, migration. It has antiapoptotic activity nephrogenesis. investigated biomarker for patients undergoing percutaneous coronary intervention (PCI) stable angina was significantly higher post PCU. However, more are needed validate its efficacy detection CI-AKI.
 
 Keywords: nephropathy, contrast-induced injury, midkine,